Details

Acute Promyelocytic Leukemia

A Clinical Guide

von: Oussama Abla, Francesco Lo Coco, Miguel A. Sanz
96,29 €
Verlag:	Springer
Format:	PDF
Veröffentl.:	25.04.2018
ISBN/EAN:	9783319642574
Sprache:	englisch

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Beschreibungen

Titelbeschreibung

<p>This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges.</p>Written by top experts in the field, <i>Acute Promyelocytic Leukemia: A Clinical Guide </i>is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.<p></p> <p></p><p></p>

Inhaltsverzeichnis

<div>1 History of APL</div><div>Laurent Degos</div><div> </div><div>2 Molecular Targets of Treatment in APL</div><div>Ramy Rahmé, Cécile Esnault, Hugues de Thé</div><div><br></div><div>3 The Leukemic Stem Cell</div><div>Thalia Vlachou, Giulia De Conti, Anna Giulia Sanarico, Pier Giuseppe Pelicci</div><div><br></div><div>4 The Molecular Genetics of APL</div><div>Lourdes Mendez, Ming Chen, Pier Paolo Pandolfi</div><div></div><br><div>5 APL Coagulopathy</div><div>Anna Falanga, Laura Russo, Pau Montesinos</div><div><br></div><div>6 Early Death in APL</div><div>Sören Lehmann</div><div><br></div><div>7 Prognostic Factors in APL</div><div>Javier de la Serna, Pau Montesinos, Miguel A. Sanz</div><div><br></div><div>8 First-line therapy for APL: Chemotherapy-based approach </div><div>Aaron D. Goldberg, Martin S. Tallman</div><div></div><br><div>9 First-line Therapy: ATRA-ATO/Reduced Chemotherapy Approach</div><div>Harry Iland</div><div><br></div><div>10 Cure of APL without Chemotherapy</div><div>Mary-Elizabeth M. Percival, Elihu H. Estey</div><div><br></div><div>11 Minimal Residual Disease in APL</div><div>Laura Cicconi, Eva Barragàn</div><div><br></div><div>12 Treatment of refractory and relapsed APL</div><div>Eva Lengfelder</div><div></div><br><div>13 Hematopoietic Stem Cell Transplantation in APL</div><div>Jaime Sanz, Miguel A. Sanz</div><div><br></div><div>14 APL in Children</div><div>Matthew A. Kutny, Anna Maria Testi</div><div><br></div><div>15 Management of APL in the Elderly</div><div>Ramy Rahmé, Lionel Adès, Pierre Fenaux</div><div><br></div><div>16 Special Situations in APL</div><div>Massimo Breccia, Gloria Iacoboni, Miguel A. Sanz</div><div></div><br><div>17 APL in Developing Countries: A Chemotherapy-Based Approach</div><div>Luisa Corrêa de Araújo Koury, Raul Ribeiro, Eduardo M. Rego</div><div><br></div><div>18 APL in Developing Countries: ATO based Approach</div><div>Vikram Mathews</div><div><br></div><div>19 Therapy-Related APL</div><div>Kristen Pettit</div>, Richard A. Larson<div><br></div><div>20 Rare Acute Leukemia Variants involving Retinoic Acid Receptor Genes</div><div></div>Laura Cicconi, Oussama Abla<div><br></div><div>21 Management of Treatment-Related Complications in APL</div><div>Ombretta Annibali, Giuseppe Avvisati</div>

Autorenportrait

<p>Oussama Abla, MD</p> <p>The Hospital for Sick Children and University of Toronto</p> <p>Division of Hematology/Oncology</p> <p>Toronto, ON</p> <p>Canada</p> <p> </p> <p>Francesco Lo-Coco, MD</p> <p>Professor of Hematology</p> University of Tor Vergata<p></p> <p>Rome</p> Italy<p></p> <p> </p> <p>Miguel A. Sanz, MD</p><p>Centro de Investigación Biomédica en Red de Cáncer</p><p>Madrid</p><p>Spain</p>

Back cover copy

<p>This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges.</p><p>Written by top experts in the field, <i>Acute Promyelocytic Leukemia: A Clinical Guide </i>is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.<br></p> <p></p><p></p>

Sonderbeitrag

<p>First comprehensive text on acute promyelocytic leukemia in the last ten years</p><p>Summarizes historical, current, and future treatment strategies</p><p>Highlights the most recent therapeutic recommendations for relapsed disease</p><p>Written by top experts in the field</p>

Verkaufsargumente

<p>First comprehensive text on acute promyelocytic leukemia in the last ten years</p> <p>Summarizes historical, current, and future treatment strategies</p> <p>Highlights the most recent therapeutic recommendations for relapsed disease </p> <p>Written by top experts in the field</p>