Details

Molecular Determinants of Head and Neck Cancer

Current Cancer Research 2nd ed. 2018

von: Barbara Burtness, Erica A. Golemis
149,79 €
Verlag:	Humana Press
Format:	PDF
Veröffentl.:	03.08.2018
ISBN/EAN:	9783319787626
Sprache:	englisch

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Beschreibungen

Titelbeschreibung

Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects.  Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer.  However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects.  This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response.  This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome.  The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response.  It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients.  Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.

Inhaltsverzeichnis

- Overview: The Pathobiology of Head and Neck Cancer. - Targeting the ErbB Family in Head and Neck Cancer. - c-MET in Head and Neck Squamous Cell Carcinoma. - Transforming Growth Factor Beta (TGF-β) Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC). - The PI3K Signaling Pathway in Head and Neck Squamous Cell Carcinoma. - Jak/STAT Signaling in Head and Neck Cancer. - Molecular Regulation of Cell Cycle and Cell Cycle-Targeted Therapies in Head and Neck Squamous Cell Carcinoma (HNSCC). - Role of the NOTCH Signaling Pathway in Head and Neck Cancer. - P53 in Head and Neck Squamous Cell Carcinoma. - APOBEC as an Endogenous Mutagen in Cancers of the Head and Neck. - The Genome-Wide Molecular Landscape of HPV-Driven and HPV-Negative Head and Neck Squamous Cell Carcinoma. - Epigenetic Changes and Epigenetic Targets in Head and Neck Cancer. - Inflammation and Head and Neck Squamous Cell Carcinoma. - Immunotherapy in Head and Neck Squamous Cell Carcinoma (HNSCC). - The Clinical Impact of Hypoxia in Head and Neck Squamous Cell Carcinoma. - Angiogenesis and Anti-angiogenic Therapy in Head and Neck Cancer. - FAK as a Target for Therapy in Head and Neck Cancer. - Diversity of Wnt/β-Catenin Signaling in Head and Neck Cancer: Cancer Stem Cells, Epithelial-to-Mesenchymal Transition, and Tumor Microenvironment. - Hyaluronan-Mediated CD44 Signaling Activates Cancer Stem Cells in Head and Neck Cancer. - Biology and Epidemiology of Human Papillomavirus-Related Head and Neck Cancer. - Treatment Paradigms in HPV-Associated SCCHN.

Autorenportrait

Barbara Burtness, M.D. is Professor of Medicine, Yale University School of Medicine and Co-Leader, Developmental Therapeutics Program, Yale Cancer Center. As Chair of the Head and Neck Committee in Eastern Cooperative Oncology Group and a member of the NCI Head and Neck Steering Committee, she helps shape the national agenda for research on all stages of head and neck cancer.Erica Golemis, Ph.D. is the Deputy Chief Scientific Officer and Co-leader of the Program in Molecular Therapeutics at the Fox Chase Cancer Center. Her research seeks to define the changes in cell signaling that occur as tumors spread by metastasis and develop resistance to drugs, with the ultimate goal of inhibiting these processes to effect disease control and cure.

Back cover copy

Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects.  Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer.  However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response.  This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome.  The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response.  It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients.  Overall,the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.

Sonderbeitrag

Summarize the unique pathobiology of head and neck cancers Addresses signaling pathways and individual proteins that are important in causing or supporting the aggressive nature of head and neck cancer Discusses the sequencing and epigenomic analysis of the head and neck cancer genome Focuses on a new understanding of stem cell function in head and neck prognosis and therapy resistance Discusses a shifting focus of care for HPV positive and HPV negative disease Addresses rising immunotherapy options, clinical trails and relevant results

Verkaufsargumente

Summarize the unique pathobiology of head and neck cancersAddresses signaling pathways and individual proteins that are important in causing or supporting the aggressive nature of head and neck cancerDiscusses the sequencing and epigenomic analysis of the head and neck cancer genome Focuses on a new understanding of stem cell function in head and neck prognosis and therapy resistanceDiscusses a shifting focus of care for HPV positive and HPV negative disease Addresses rising immunotherapy options, clinical trails and relevant results