This edition first published 2018
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Library of Congress Cataloging‐in‐Publication Data
Names: Bellelli, Andrea, 1958– author. | Carey, Jannette, author.
Title: Reversible ligand binding : theory and experiment / by Andrea Bellelli, Jannette Carey.
Description: First edition. | Hoboken, NJ : John Wiley & Sons, 2018. | Includes bibliographical references and index. |
Identifiers: LCCN 2017026931 (print) | LCCN 2017040990 (ebook) | ISBN 9781119238478 (pdf) | ISBN 9781119238492 (epub) | ISBN 9781119238485 (cloth)
Subjects: LCSH: Ligand binding (Biochemistry)
Classification: LCC QP517.L54 (ebook) | LCC QP517.L54 B45 2017 (print) | DDC 572/.33–dc23
LC record available at https://lccn.loc.gov/2017026931
Cover design by Wiley
Cover Image: Courtesy of RCSB Protein Data Bank (entry 1vyf, deposited by Angelucci et al. 2004)
A.B. dedicates this book to Maurizio Brunori, teacher, mentor and friend for thirty‐eight years until now and with more to come.
Ligand binding is a crucial event in virtually every biological phenomenon. Detailed understanding of many biologically relevant events including enzymatic catalysis, transport, and molecular recognition requires quantitative description of ligand binding. Such description may prove exquisitely complex because biological macromolecules may bind multiple ligands at once or alternatively and their reactions may present several types of thermodynamic linkage. The scope of this book is to provide a comprehensive view of the various biochemical considerations that govern reversible as well as irreversible ligand binding. Special attention is devoted to enzymology, a field usually treated separately from ligand binding, but actually governed by identical thermodynamic relationships.