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<div><br></div><div><div><div>Part I: Introduction to Neuromuscular Pathology Evaluation</div><div><br></div><div>1 Skeletal Muscle Biopsy Evaluation</div><div> Dennis K. Burns</div><div><br></div><div>2 Peripheral Nerve Biopsy Evaluation</div><div> Chunyu Cai</div><div><br></div><div>3 Skin Biopsy with Cutaneous Nerve Fiber Evaluation</div><div> Lan Zhou</div><div><br></div><div>Part II: Myopathy Cases</div><div><br></div><div>4 A 20-year-old man with acute multi-organ failure and rhabdomyolysis</div><div> Lan Zhou and Susan C. Shin</div><div><br></div><div>5 A 45-year-old woman with proximal limb weakness and skin peeling on fingertips</div><div> Lan Zhou, Susan C. Shin, and Chunyu Cai</div><div><br></div><div>6 A 75-year-old man with leg and hand weakness</div><div> Lan Zhou and Chunyu Cai</div><div><br></div><div>7 A 53-year-old woman with proximal limb weakness and marked CK elevation</div><div> Lan Zhou and Chunyu Cai</div><div><br></div>8 A 61-year-old woman with distal limb and deltoid weakness</div><div> Lan Zhou</div><div><br></div><div>9 A 63-year-old woman with debilitating muscle pain</div><div> Lan Zhou</div><div><br></div><div>10 A 33-year-old woman with pain and swelling in the right calf and persistent fever</div><div> Lan Zhou, Laura Stein, and Susan C. Shin</div><div><br></div><div>11 A 28-year-old woman with proximal limb weakness and scapular winging</div><div> Jaya R. Trivedi, Chunyu Cai, and Rahul Abhyankar</div><div><br></div>12 A 52-year-old man with proximal limb weakness and hand stiffness</div><div> Lan Zhou and Susan C. Shin</div><div><br></div><div>13 A 51-year-old woman with long-standing exercise intolerance</div><div> Lan Zhou</div><div><br></div>14 A 37-year-old woman with leg weakness<div> Elisabeth Golden and Lan Zhou</div><div><br></div><div>15 A 25-year-old woman with droopy eyelids and double vision</div><div> Lan Zhou and Chunyu Cai</div><div><br></div><div>16 A 58-year-old man with hypercapnic respiratory failure</div><div> Lan Zhou, Patrick Kwon, and Susan C. Shin</div><div><br></div><div>17 A 65-year-old man with asymmetrical leg weakness and foot tingling</div><div> Lan Zhou and Chunyu Cai</div><div><br></div><div>18 A 40-year-old man with muscle pain and fatigue</div><div> Lan Zhou</div><div><br></div><div>19 A 42-year-old woman with progressive limb weakness and breathing difficulty</div><div> Lan Zhou and Dennis K Burns</div><div><br></div><div>20 A 49-year-old man with limb weakness and skin changes</div><div> Kara Stavros, Rajeev Motiwala, Lan Zhou, and Susan C. Shin</div><div><br></div><div>21 A 54-year-old man with lower limb weakness</div><div> Lan Zhou</div><div><br></div><div>22 A 63-year-old man with progressive limb weakness and slurred speech</div><div> Lan Zhou and Susan C. Shin</div><div><br></div><div>23 A 6-year-old girl with muscle pain and swelling in the thighs</div><div> Diana P. Castro, Chunyu Cai, and Dustin Jacob Paul</div><div><br></div><div>24 A 4-year-old boy with progressive weakness, difficulty walking and running, and increased falls</div><div> Diana P. Castro, Chunyu Cai, and Dustin Jacob Paul</div><div><br></div><div>25 A 2-year-old girl with hypotonia since birth and delayed motor and speech development</div><div> Diana P. Castro, Chunyu Cai, Dustin Jacob Paul</div><div><br></div><div>26 An 8-year-old boy with delayed motor milestones and proximal leg muscle weakness</div><div> Partha S. Ghosh and Hart G. W. Lidov</div><div><br></div><div>27 A 6-year-old-boy with proximal leg muscle weakness and facial weakness</div><div> Partha S. Ghosh and Hart G. W. Lidov</div><div><br></div><div>28 A 6-week-old boy with neonatal hypotonia and feeding and respiratory difficulties</div><div> Partha S. Ghosh and Hart G. W. Lidov</div><div><br></div><div>29 A 6-year-old boy with respiratory and feeding difficulties at birth, delayed gross motor milestones, and facial and proximal lower limb weakness</div><div> Partha S. Ghosh and Chunyu Cai</div><div><br></div><div>30 A 12-year-old girl with a 2-year history of progressive weakness and difficulties with exercise</div><div> Diana P. Castro, Chunyu Cai, and Dustin Jacob Paul</div><div><br></div><div>31 A 3-month-old boy with generalized hypotonia, weakness, pneumonia and respiratory failure</div><div> Diana P. Castro, Chunyu Cai, and Dustin Jacob Paul</div><div><br></div><div>Part III: Neuropathy Cases</div><div><br></div><div>32 A 59-year-old woman with subacute lower limb weakness and painful paresthesia</div><div> Shaida Khan and Chunyu Cai</div><div><br></div><div>33 A 63-year-old man with nausea, vomiting, orthostatic dizziness, and distal limb paresthesia</div><div> Jeffrey L. Elliott, Lan Zhou, Chunyu Cai, and Michelle Kaku</div><div><br></div><div>34 A 47-year-old woman with progressive numbness and weakness in the limbs</div><div> Lingchao Meng, Yun Yuan, and Shan Chen</div><br><div>35 A 65-year-old woman with acute limb weakness and worsening of paresthesia</div><div> Susan C. Shin, Michelle Kaku, and Lan Zhou</div><div><br></div><div>36 A 34-year-old man with right hand and left foot numbness</div><div> Sharon P. Nations and Dennis K. Burns</div><div><br></div><div>37 A 64-year-old woman with progressive pain, numbness and weakness in the right lower limb</div><div> Lan Zhou, Susan Morgello, Rajeev Motiwala, and Susan C. Shin</div><div><br></div><div>38 A 68-year-old man with progressive lower limb numbness and weakness and urinary incontinence</div><div> Lan Zhou, Susan Morgello, and Susan C. Shin</div><div><br></div><div>39 A 53-year-old woman with pain, burning, tingling, and numbness in the distal limbs</div><div> Lan Zhou</div><div><br></div><div>40 A 40-year-old woman with patchy painful paresthesia</div><div> Lan Zhou</div><div><br></div><div>41 A 39-year-old woman with intermittent bilateral foot and leg pain since childhood</div><div> Ryan Castoro, Jun Li, and Lan Zhou</div><div><br></div><div>42 A 35-year-old man with pain and numbness in the left lateral thigh</div><div> Lan Zhou</div><div><br></div>

<div><div>Lan Zhou, MD, PhD<br></div><div><div>Departments of Neurology and Pathology</div><div>Boston University Medical Center</div><div>Boston, MA&nbsp;</div><div>USA</div><div><br></div></div><div>Dennis K. Burns, MD</div><div>Department of Pathology</div><div>Neuropathology Section</div><div>The University of Texas Southwestern Medical Center</div><div>Dallas, TX&nbsp;</div><div>USA</div><div><br></div><div>Chunyu Cai, MD, PhD</div><div>Department of Pathology</div><div>The University of Texas Southwestern Medical Center</div><div>Dallas, TX&nbsp;</div><div><br></div></div><div><br></div>

<div><div>This book provides a practical guide to the field of neuromuscular pathology including muscle, peripheral nerve, and skin biopsies with biopsy interpretation. Divided into three parts, the book begins with introductory chapters that review muscle, nerve, and skin biopsy indications and procedures, normal muscle and nerve histology, and common muscle and nerve pathology. The 28 myopathy case chapters in Part 2 and 11 neuropathy case chapters in Part 3 illustrate the clinical and pathological features of many neuromuscular diseases, demonstrate the indications and utilities of biopsies, discuss clinical and pathological differential diagnosis, update the individual disease management, and summarize pertinent clinical and pathology pearls for each case.&nbsp;<i><br></i></div><div><br></div><div><i>A Case-Based Guide to Neuromuscular Pathology</i>&nbsp;will function as an indispensable reference for neurologists and pathologists looking to understand the utility of muscle, nerve, and skin biopsies. This book will also aid neurology residents, neuromuscular fellows and neuropathology fellows in preparing for questions related to the muscle and nerve pathology in their in-service and board exams.&nbsp;<br></div><div><br></div></div>

<p>Provides a practical overview of neuromuscular pathology - muscle, nerve and skin biopsies and biopsy interpretation</p><p>Offers neurologists and trainees useful clinical and pathology pearls to facilitate their learning of neuromuscular pathology and management of a variety of myopathies and neuropathies</p><p>Features a variety of educational cases that demonstrate biopsy utilities, clinical and pathological correlations, and individual disease management</p>