Details

DJ-1/PARK7 Protein


DJ-1/PARK7 Protein

Parkinson's Disease, Cancer and Oxidative Stress-Induced Diseases
Advances in Experimental Medicine and Biology, Band 1037

von: Hiroyoshi Ariga, Sanae M. M. Iguchi-Ariga

149,79 €

Verlag: Springer
Format: PDF
Veröffentl.: 16.11.2017
ISBN/EAN: 9789811065835
Sprache: englisch

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Beschreibungen

This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The <i>DJ-1 </i>gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The <i>DJ-1</i> gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of <i>DJ-1</i>, and explains the history and research development to understand the following chapters. Those chapters present the roles of <i>DJ-1</i> in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader willdiscover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. <p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p>
<p>Preface.- Chapter 1 Introduction/Overview.- Chapter 2 Structural Biology of the DJ-1 Superfamily.- Chapter 3 Expression of DJ-1 in patients with neurodegenerative diseases.- Chapter 4 DJ-1 as an oncogene and its clinical significance.- Chapter 5 Role of DJ-1 in fertilization.- Chapter 6 Anti-oxidative stress function of DJ-1.- Chapter 7 Ttranscriptional regulation of DJ-1.- Chapter 8 Regulation of Signal Transduction by DJ-1.- Chapter 9 Protein repair by DJ-1 from glycation by glyoxal and methylglyoxal.- Chapter 10 DJ-1 as a biomarker of Parkinson's disease.- Chapter 11 Roles of DJ-1 in diabetes mellitus .- Chapter 12 Therapeutic activities of DJ-1 and its binding compounds against neurodegenerative diseases.- Chapter 13 DJ-1 as an oncogene and promising target for cancer chemotherapy. </p><p></p>
<div><b>Hiroyoshi Ariga</b><br/>Faculty of Pharmaceutical Sciences, Hokkaido University<br/>Sapporo, Japan<br/><br/><b>Sanae M.M. Iguchi‐Ariga<br/></b>Faculty of Agriculture, Hokkaido University</div><div>Sapporo,Japan</div>
<p>This book reviews the functions and roles of DJ-1 in various oxidative stress-related diseases and applications of DJ-1 and its binding compounds to the diseases. The <i>DJ-1 </i>gene was first found to be a novel oncogene in 1997 and later, in 2003, also found to be a causative gene for a familial form of Parkinson’s disease (PD), park7. The <i>DJ-1</i> gene is therefore the first gene discovered that is known to cause cancer and neurodenegerative diseases, including PD. The research field has expanded as the research has developed. Thus this volume begins with a general introduction of <i>DJ-1</i>, and explains the history and research development to understand the following chapters. Those chapters present the roles of <i>DJ-1</i> in various oxidative stress-related diseases such as neurodegenerative diseases, as well as cancer, diabetes, and fertility. Moreover, several chapters present evidence that DJ-1 is useful for therapeutic strategies against these diseases. The reader will discover that DJ-1 is a promising protein both for basic cell biology and for the mechanism and therapy for oxidative stress-related diseases. </p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p><p></p>
Covers various oxidative stress-related diseases, including cancer, neurodegenerative diseases, and type 2 diabetes as well as male infertility Broadens the understanding of the various uses of DJ-1 such as a biomarker for diagnosis of neurodegenerative diseases Enriches understanding of DJ-1-binding compounds which are promising drugs for various oxidative stress-related diseases
<p>Covers various oxidative stress-related diseases, including cancer, neurodegenerative diseases, and type 2 diabetes as well as male infertility</p><p>Broadens the understanding of the various uses of DJ-1 such as a biomarker for diagnosis of neurodegenerative diseases</p><p>Enriches understanding of DJ-1-binding compounds which are promising drugs for various oxidative stress-related diseases</p>

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