Details

Functional Nucleic Acids for Analytical Applications


Functional Nucleic Acids for Analytical Applications


Integrated Analytical Systems

von: Yingfu Li, Yi Lu

96,29 €

Verlag: Springer
Format: PDF
Veröffentl.: 27.05.2009
ISBN/EAN: 9780387737119
Sprache: englisch
Anzahl Seiten: 395

Dieses eBook enthält ein Wasserzeichen.

Beschreibungen

<P>Nature has long used nucleic acid aptamers and enzymes for regulatory activities, such as the recently discovered “riboswitches” involved in gene expression. The existence of a large array of natural and artificial functional nucleic acids has generated tremendous enthusiasm and new opportunities for molecular scientists from diverse disciplines to devise new concepts and real applications that take advantage of those nucleic acids for sensing and other analytical applications. This book provides a timely and comprehensive overview of recent advances in the field, from leading experts in biology, chemistry, and engineering. A variety of topics are covered, from fundamentals of functional nucleic acids, to their applications as sensors, to nanotechnologies; as well as integration of functional nucleic acids into practical analytical systems.</P>
Overview of Functional Nucleic Acids and Their Analytical Applications.- Introductory Remarks.- Natural Functional Nucleic Acids: Ribozymes and Riboswitches.- Artificial Functional Nucleic Acids: Aptamers, Ribozymes, and Deoxyribozymes Identified by In Vitro Selection.- Functional Nucleic Acid Sensors Based on Different Transduction Principles.- Fluorescent Aptamer Sensors.- Fluorescent Ribozyme and Deoxyribozyme Sensors.- Colorimetric and Fluorescent Biosensors Based on Directed Assembly of Nanomaterials with Functional DNA.- Electrochemical Approaches to Aptamer-Based Sensing.- Amplified DNA Biosensors.- Other Emerging Analytical Applications.- Aptamers in Affinity Separations:Capillary Electrophoresis.- Aptamers in Affinity Separations: Stationary Separation.- Aptamer Microarrays.- The Use of Functional Nucleic Acids in Solid-Phase Fluorimetric Assays.- Functional Nucleic Acid Sensors as Screening Tools.- Nucleic Acids for Computation.- DNAzymes in DNA Nanomachines and DNA Analysis.
<P>Both DNA and RNA can serve purposes beyond simple genetic storage and transfer – for example, they can also be employed as enzymes (for catalysis) and receptors (for ligand binding). Increasingly, researchers are making interesting use of these molecules, now collectively called functional nucleic acids. This book, containing chapters written by leading experts in relevant fields, provides timely accounts of diverse analytical applications that take advantage of the functional nucleic acids. The book is written for academic, clinical and industrial scientists and graduate students who may consider exploring functional nucleic acids in their research or practice.</P>
First in the rapidly emerging field on analytical applications for nucleic acids With interdisciplinary approach, a valuable tool for researchers in chemistry, biology, and engineering One of the first books in the series Integrated Microanalytical Systems, recently renamed Integrated Analytical Systems, edited by R. Potyrailo
<P>This is the first book in the rapidly emerging field of analytical applications for nucleic acids. The existence of a large array of natural and artificial functional nucleic acids has generated tremendous enthusiasm. It has opened up new opportunities for molecular scientists from diverse disciplines to devise new concepts and real applications that take advantage of those nucleic acids for sensing and other analytical applications. This book provides a timely and comprehensive overview of recent advances in the field, from leading experts in biology, chemistry, and engineering. A variety of topics are covered, from fundamentals of functional nucleic acids, to their applications as sensors, to nanotechnologies; as well as integration of functional nucleic acids into practical analytical systems.</P>

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