Details

Immunotherapy in Translational Cancer Research


Immunotherapy in Translational Cancer Research


Translational Oncology 1. Aufl.

von: Laurence J. N. Cooper, Elizabeth A. Mittendorf, Judy Moyes, Sabitha Prabhakaran

179,99 €

Verlag: Wiley-Blackwell
Format: PDF
Veröffentl.: 08.02.2018
ISBN/EAN: 9781118684504
Sprache: englisch
Anzahl Seiten: 312

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Beschreibungen

<p><b>A guide to state-of-the-art cancer immunotherapy in translational cancer research</b><b> </b></p> <p>A volume in the <i>Translational Oncology</i> series, <i>Immunotherapy in Translational Cancer Research</i> explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, <i>Immunotherapy in Translational Cancer Research</i> reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues.</p> <p>Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world’s foremost cancer research and care center and: </p> <ul> <li>Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care </li> <li>Filled with the concepts, examples, and approaches for developing individualized therapy</li> <li>Explores the breath of treatments that reflect the complexity of the immune system itself</li> <li>Includes contributions from a panel international experts in the field of immunotherapy</li> </ul> <p>Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research.</p>
<p>Editors vi</p> <p>Contributors vii</p> <p>Introduction ix</p> <p>1 Translation in Immunology: The Role of Translational Biomarkers to Guide Clinical Use of Immunotherapy for Cancer 1<br /><i>Saranya Chumsri and Keith L. Knutson</i></p> <p>2 Monoclonal Antibody Therapy 12<br /><i>Elizabeth A. Mittendorf and Sabitha Prabhakaran</i></p> <p>3 Somatic Mutations and Immunotherapy 24<br /><i>Eric Tran</i></p> <p>4 Checkpoint Blockade 37<br /><i>Tracy A. Proverbs‐Singh Jedd Wolchok and Alexandra Snyder</i></p> <p>5 Myeloid Leukemia Vaccines 54<br /><i>Paul M. Armistead and Jonathan S. Serody</i></p> <p>6 Cancer Vaccines for Solid Tumors 72<br /><i>Timothy J. Vreeland Garth S. Herbert and George E. Peoples</i></p> <p>7 Immunotherapy with Non–Genetically Modified T Cells 91<br /><i>Cassian Yee</i></p> <p>8 Immunotherapy with Genetically Modified T Cells 101<br /><i>Liora Schultz and Crystal Mackall</i></p> <p>9 Immunomodulation with Adjuvants and Cytokines 115<br /><i>Dae won Kim and Adi Diab</i></p> <p>10 Immune Cell Migration in Cancer and Immunotherapy 132<br /><i>Timothy Murray and Daniel E. Speiser</i></p> <p>11 Repurposing of Drugs for Immunotherapy 143<br /><i>Jyothishmathi Swaminathan and Vidya Gopalakrishnan</i></p> <p>12 Immunomodulation with Radiation 161<br /><i>Jonathan E. Schoenhals Taylor R. Cushman, Alexandra P. Cadena Sandra Demaria and James W. Welsh</i></p> <p>13 Good Manufacturing Practices Facilities for Cellular Therapy 177<br /><i>Andrew D. Fesnak and Bruce L. Levine</i></p> <p>14 T Cell Receptor Mimic Antibodies 186<br /><i>Gheath Alatrash and Jeffrey J. Molldrem</i></p> <p>15 Stem Cell Transplantation for Treatment of Malignancy 201<br /><i>Lohith S. Bachegowda and Richard E. Champlin</i></p> <p>16 Natural Killer Cell–Based Immunotherapy 215<br /><i>Jennifer A. Foltz Jeffrey S. Miller and Dean A. Lee</i></p> <p>17 Immunologic Monitoring in Immuno‐Oncology 228<br /><i>William R. Gwin and Mary L. Disis</i></p> <p>18 Cell‐Based Therapies for Canine Cancer 252<br /><i>Nicola J. Mason and M. Kazim Panjwani</i></p> <p>19 Interaction between Targeted Therapy and Immunotherapy 268<br /><i>Peter A. Prieto Miles C. Andrews, Alexandria P. Cogdill, and Jennifer A. Wargo</i></p> <p>Index 286</p>
<p> <strong>Laurence J. N. Cooper,</strong> Associate Professor, Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, USA. <p><strong>Elizabeth A. Mittendorf,</strong> Professor, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA. <p><strong><strong>Judy Moyes,</strong></strong> Department of Pediatric Research, The University of Texas MD Anderson Cancer Center, Houston, USA. <p><strong>Sabitha Prabhakaran,</strong> Clinical Research Scientist, Department of Breast Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, USA.
<p> <strong>A guide to state-of-the-art cancer immunotherapy in translational cancer research</strong> <p> A volume in the Translational Oncology series, <em>Immunotherapy in Translational Cancer Research</em> explores the recent developments in the role that immunotherapy plays in the treatment of a wide range of cancers. The editors present key concepts, illustrative examples, and suggest alternative strategies in order to achieve individualized targeted therapy. Comprehensive in scope, <em>Immunotherapy in Translational Cancer Research</em> reviews the relevant history, current state, and the future of burgeoning cancer-fighting therapies. The book also includes critical information on drug development, clinical trials, and governmental resources and regulatory issues. <p> Each chapter is created to feature: development of the immunotherapy; challenges that have been overcome in order to scale up and undertake clinical trials; and clinical experience and application of research. This authoritative volume is edited by a team of noted experts from MD Anderson Cancer Center, the world???s foremost cancer research and care center and: <ul> <li>Offers a comprehensive presentation of state-of-the-art cancer immunotherapy research that accelerates the pace of clinical cancer care</li> <li>Filled with the concepts, examples, and approaches for developing individualized therapy</li> <li>Explores the breath of treatments that reflect the complexity of the immune system itself</li> <li>Includes contributions from a panel international experts in the field of immunotherapy</li> </ul> <br> <p> Designed for physicians, medical students, scientists, pharmaceutical executives, public health and public policy government leaders and community oncologists, this essential resource offers a guide to the bidirectional interaction between laboratory and clinic immunotherapy cancer research

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