Details

Role of Capsaicin in Oxidative Stress and Cancer


Role of Capsaicin in Oxidative Stress and Cancer


Diet and Cancer, Band 3

von: Sanjay K. Srivastava

96,29 €

Verlag: Springer
Format: PDF
Veröffentl.: 23.04.2013
ISBN/EAN: 9789400763173
Sprache: englisch
Anzahl Seiten: 178

Dieses eBook enthält ein Wasserzeichen.

Beschreibungen

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.
<p>Preface.- Role of capsaicin in cancer prevention.- Role of death receptors belonging to the TNF family in capsaicin-induced apoptosis of tumor<b> </b>cells.- Role of capsaicin in prostate cancer.- Capsaicin and the urinary bladder.- Inhibition of pancreatitis and carcinogenesis by capsaicin.- Cytochrome P450-dependent modification of capsaicinoids:  pharmacological inactivation and bioactivation mechanisms.- The cancer suppressing and promoting actions of capsaicin.- Oxidative stress by capsaicin in cancer.<b></b></p>
<p>Capsaicin is a principal pungent ingredient of red chili peppers, first isolated in the early nineteenth century by Christian Friedrich Bucholz. Widely consumed as a spice in South Asia and Latin America, Capsaicin has been used to treat pain and inflammation associated with a variety of diseases, including rheumatoid arthritis, diabetic neuropathy, post-masectomy pain, cluster headaches, and herpes zoster. Although recent studies have evaluated capsaicin as a novel anti-cancer agent, and mechanisms of capsaicin in preventing cancer have been described sporadically, the literature lacks a comprehensive review of capsaicin as a chemo-preventive agent. </p><p><p><i>Role of Capsaicin in Oxidative Stress and Cancer</i> offers a thorough exploration of the preventive and therapeutic effects of capsaicin in cancer models such as melanoma, pancreatic cancer, colon cancer, gastric cancer, breast cancer, prostate cancer, skin cancer, lung cancer, multiple myeloma and glioma.  </p><p><p>The contributors, all internationally recognized researchers, identify various molecular and cellular targets of capsaicin, and show the critical role of mitochondria in capsaicin-mediated therapeutic effects. Readers will learn how capsaicin prevents or may treat cancer, how different cells respond to capsaicin, how environmental carcinogen-induced carcinogenesis can be prevented by capsaicin and the mechanism of oxidative stress caused by capsaicin.  This book will benefit medical students, oncologists and cancer researchers everywhere.</p><p>
Thoroughly reviews the preventive and therapeutic effects of capsaicin in melanoma, pancreatic cancer, colon cancer, breast cancer, lung cancer, multiple myeloma and others Identifies molecular and cellular targets of capsaicin and describes the role of mitochondria in capsaicin-mediated therapeutic effects Benefits medical students, oncologists and cancer researchers

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